| 54 | |
| Summary | Gut microbes (currently unknown members) affect Sulfinpyrazone's reduction. |
| Gut | |
| Sulfinpyrazone (PubChem CID: 5342) | |
| unknown | |
| 3630204 | |
| affect reduction | |
| The gut microbiota reduce sulfinpyrazone, a drug used to treat gout and gouty arthritis, into sulfinpyrazone sulfide metabolite. Of note, ex vivo experiments showed that human feces reduced sulindac more extensively than sulphinpyrazone. Further in vivo experiments, which used metronidazole and tetracycline as antibiotics against anaerobic and aerobic bacteria, respectively, demonstrated that anaerobic intestinal bacteria are the key players the reduction of these sulphoxide-containing drugs. |
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