PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) affect Sulindac's reduction.
Sulindac (PubChem CID: 1548887)
affect reduction
Sulindac, a nonsteroid anti-inflammatory analgesic, is reduced by the human gut microbiota to sulindac sulfide. Of note, ex vivo experiments showed that human feces reduced sulindac more extensively than sulphinpyrazone. Further in vivo experiments, which used metronidazole and tetracycline as antibiotics against anaerobic and aerobic bacteria, respectively, demonstrated that anaerobic intestinal bacteria are the key players the reduction of these sulphoxide-containing drugs.

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