PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Clostridium sporogenes) affect zonisamide's reduction.
zonisamide (PubChem CID: 5734)
Clostridium sporogenes (Tax ID: 1509)
affect reduction
Zonisamide is an anticonvulsant drug. It is primarily metabolized to 2-sulfamoyalcetylphenol by reduction of the benzisoxazole ring. Studies concluded that intestinal bacteria play a major role in this reductive metabolism. This role was confirmed in an experiment in which rats were treated by antibiotics, which reduced sulfamoyalcetylphenol excretion, but the metabolite levels were restored upon recontamination of the rats with the cecal microbiota. Clostridium sporogenes had the highest zonisamide reductase activity out of eight bacterial strains tested.

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