| 62 | |
| Summary | Gut microbes (currently unknown members) affect phenacetin's acetylation. |
| Gut | |
| phenacetin (PubChem CID: 4754) | |
| unknown | |
| 4418213 | |
| affect acetylation | |
| The rat caecal microbiota is able to deacylate phenacetin and certain related compounds to the corresponding primary amines in vitro, while other N-acylated drugs resisted microbial deacylation. When rat caecal contents were incubated with phenacetin under anaerobic conditions, the deacetylation reaction involved in forming of p-phenetidin could be demonstrated. |
Browse Drug-Microbiome Relationship
Home