PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) increase 2-methoxyestrone's activity.
Gut
2-methoxyestrone (PubChem CID: 440624)
unknown
6299367
increase activity
Gut microbiota are believed to convert 2-methoxy esterone to the active steroid form. Upon incubation of 2-methoxy esterone with isolated cecum of rats, two different reactions were found to take place: oxidoreduction at C17 and demethylation at C2 resulting into the active form.

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