| 7 | |
| Summary | Gut microbes (currently unknown members) affect zonisamide's reduction. |
| Gut | |
| zonisamide (PubChem CID: 5734) | |
| unknown | |
| 9231340 | |
| affect reduction | |
| The gut microbiota is central to the metabolism of zonisamide through a reduction reaction that produces 2-sulfomoyacetylphenol. When the level of this metabolite was measured in conventional rats and germ-free rats, germ-free rats showed lower levels. This was further confirmed as the the levels of 2-sulfomoyacetylphenol increased upon re-inoculation of the germ-free rats with gut microbiota. |
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