PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) affect zonisamide's reduction.
Gut
zonisamide (PubChem CID: 5734)
unknown
9231340
affect reduction
Gut microbiota is central to the metabolism of zonisamide by reduction producing 2-sulfomoyacetylphenol. Upon measuring the level of this metabolite between conventional rats and germ-free rats, germ-free rats showed lower levels. This has been further confirmed by the incraese in the levels of 2-sulfomoyacetylphenol by re-inoculation of the germ-free rats with gut microbiota.

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