PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (phylum: Firmicutes) increase cyclophosphamide's activity.
Gut
cyclophosphamide (PubChem CID: 2907)
Firmicutes (Tax ID: 1239)
24264990
increase activity
Gram-positive bacteria, translocated into secondary lymphoid organs upon treatment with cyclophosphamide, stimulate the generation of T helper 17 (pT(H)17) cells and memory T(H)1 immune responses. These T cells boost the anticancer effect of cyclophosphamide.

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