PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

Detailed View

Summary Environmental microbes (species: Sphingomonas sp. Ibu-2) increase ibuprofen's degradation.
ibuprofen (PubChem CID: 3672)
Sphingomonas sp. Ibu-2 (Tax ID: 412900)
increase degradation
Sphingomonas Ibu-2 has the unusual ability to cleave the acid side chain of ibuprofen and related arylacetic acid derivatives to yield corresponding catechols (e.g., isobutylcatechol) under aerobic conditions. Candidate enzymes identified are: 1) ipfABDEF, whose predicted amino acid sequences bore similarity to the large and small units of an aromatic dioxygenase (ipfAB), 2) a sterol carrier protein X (SCPx) thiolase (ipfD), 3) a domain of unknown function 35 (DUF35) protein (ipfE) 4) an aromatic CoA ligase (ipfF) 5) two additional ORFs, ipfH and ipfI, which encode putative ferredoxin reductase and ferredoxin components

Browse Drug-Microbiome Relationship