| 71 | |
| Summary | Environmental microbes (species: Sphingomonas sp. Ibu-2) increase ibuprofen's degradation. |
| Environmental | |
| ibuprofen (PubChem CID: 3672) | |
| Sphingomonas sp. Ibu-2 (Tax ID: 412900) | |
| 23329679 | |
| increase degradation | |
| Sphingomonas Ibu-2 has the unusual ability to cleave the acid side chain of ibuprofen and related arylacetic acid derivatives to yield corresponding catechols (e.g., isobutylcatechol) under aerobic conditions. Candidate proteins/enzymes identified are the products of five ORFs within the ipfABDEF operon, whose amino acid sequences are similar to: (1) the large and small units of an aromatic dioxygenase (ipfAB); (2) a sterol carrier protein X, SCPx, thiolase (ipfD); 3) a domain of unknown function 35 (DUF35) protein (ipfE); 4) an aromatic CoA ligase (ipfF); 5) two putative ferredoxin reductase and ferredoxin components (ipfH and ipfI). |
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