PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) decrease Geniposide's bioavailability.
Gut
Geniposide (PubChem CID: 107848)
unknown
25257195
decrease bioavailability
In antibiotics-treated rats, the systemic exposure of geniposide was greater than in control rats while the intact drug was much higher in feces. These findings suggest that the gut microbes metabolize geniposide, and when the metabolic activity of these microbes is inhibited by antibiotic treatment, the bioavailability of geniposide increases.

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