PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (species: Eggerthella lenta) increase digoxin's reduction.
Gut
digoxin (PubChem CID: 2724385)
Eggerthella lenta (Tax ID: 84112)
23869020
increase reduction
In 2013, the genetic basis for digoxin reduction by the gut microbe Eggerthella lenta was finally uncovered. A cytochrome-encoding operon consisting of two genes (named the cardiac glycoside reductases: cgr1 and cgr2) was found to be predictive of digoxin inactivation. This operon is upregulated by digoxin, inhibited by arginine, and present in some, but not all, E. lenta strains. The operon is actually absent in nonmetabolizing E. lenta strains.

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