PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (species: Escherichia coli) affect Irinotecan's glucuronidation.
Irinotecan (PubChem CID: 60838)
Escherichia coli (Tax ID: 562)
affect glucuronidation
Irinotecan hydrochloride (CPT-11) an antitumer drug, causes sever dairrhea clincally and sever cecum damage histologically. This toxicity have been attributed to the activity of beta-glucuronidase enzyme which is produced by the intestinal microbiota, which converts CPT-11 to its active form (7-ethyl-10-hydroxycamptothecin). Inhibition of the beta-glucuronidase activity in the intestinal microflora by antibiotics (1 mg penicillin and 2 mg streptomycin per ml of drinking water) markedly ameliorated the diarrhea and reduced cecal damage

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