PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (species: Escherichia coli) affect Irinotecan's glucuronidation.
Irinotecan (PubChem CID: 60838)
Escherichia coli (Tax ID: 562)
affect glucuronidation
Irinotecan hydrochloride (CPT-11), an antitumor drug, causes severe diarrhea clinically and severe cecum damage histologically. This toxicity has been attributed to the activity of beta-glucuronidase enzymes produced by the gastrointestinal microbiota, which convert CPT-11 to its active form (7-ethyl-10-hydroxycamptothecin). Inhibition of the beta-glucuronidase activity by antibiotics (1 mg penicillin and 2 mg streptomycin per ml of drinking water) markedly ameliorated the diarrhea and reduced cecal damage.

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