| 74 | |
| Summary | Gut microbes (species: Escherichia coli) affect Irinotecan's glucuronidation. |
| Gut | |
| Irinotecan (PubChem CID: 60838) | |
| Escherichia coli (Tax ID: 562) | |
| 8706020 | |
| affect glucuronidation | |
| Irinotecan hydrochloride (CPT-11), an antitumor drug, causes severe diarrhea clinically and severe cecum damage histologically. This toxicity has been attributed to the activity of beta-glucuronidase enzymes produced by the gastrointestinal microbiota, which convert CPT-11 to its active form (7-ethyl-10-hydroxycamptothecin). Inhibition of the beta-glucuronidase activity by antibiotics (1 mg penicillin and 2 mg streptomycin per ml of drinking water) markedly ameliorated the diarrhea and reduced cecal damage. |
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