PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (species: Escherichia coli) affect Irinotecan's glucuronidation.
Gut
Irinotecan (PubChem CID: 60838)
Escherichia coli (Tax ID: 562)
8706020
affect glucuronidation
Irinotecan is a drug used as chemotherapy for colorectal cancer. Irinotecan causes toxic side effects in patients and this toxicity has been attributed to the activity of beta-glucuronidase enzyme which is produced by the intestinal microbiota.

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