PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Unknown microbes (currently unknown members) increase Fluoxetine's degradation.
Fluoxetine (PubChem CID: 3386)
increase degradation
Fluoxetine was shown to be mainly eliminated through biodegradation. A study compared the biodegradation potential of three degrading microbial consortia: an ammonium-nitrite-oxidizing consortium, a nitrite-oxidizing consortium, and a heterotrophic consortium. The heterotrophic consortium showed the highest ability (85%) to biodegrade fluoxetine, followed by the ammonium-nitrite-oxidizing consortium (79%). On the other hand, the nitrite-oxidizing consortium had the lowest biodegradation ability (< 48%).

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