PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) increase l‑carnitine's toxicity.
Gut
l‑carnitine (PubChem CID: 10917)
unknown
23563705
increase toxicity
The gut microbiota converts dietary [choline and] L-carnitine to trimethylamine (TMA), which is further metabolized by the flavine monooxygenase system in the liver to produce the toxic metabolite TMA-N-oxide (TMAO)

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