PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Bacteroides) increase sorivudine's hydrolysis.
sorivudine (PubChem CID: 5282192)
Bacteroides (Tax ID: 816)
increase hydrolysis
A toxic interaction has been reported in 18 Japanese people upon concomitant administration of sorivudine orally and 5-fluorouracil (5-FU). The resident intestinal anaerobic Bacteroides hydrolyze sorivudine, producing a high blood concentration of 5-(E)-(2-bromovinyl)uracil, which in turn increases the level and toxicity of 5-fluorouracil by deactivating dihydropyrimidine dehydrogenase, DPD (Nakayama et al, 1997).

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