| 8 | |
| Summary | Gut microbes (genus: Bacteroides) increase sorivudine's hydrolysis. |
| Gut | |
| sorivudine (PubChem CID: 5282192) | |
| Bacteroides (Tax ID: 816) | |
| 9110360 | |
| increase hydrolysis | |
| A toxic interaction has been reported in 18 Japanese people upon concomitant administration of sorivudine orally and 5-fluorouracil (5-FU). The resident intestinal anaerobic Bacteroides hydrolyze sorivudine, producing a high blood concentration of 5-(E)-(2-bromovinyl)uracil, which in turn increases the level and toxicity of 5-fluorouracil by deactivating dihydropyrimidine dehydrogenase, DPD (Nakayama et al, 1997). |
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