PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) increase L-tryptophan's toxicity.
Gut
L-tryptophan (PubChem CID: 6305)
unknown
25263219
increase toxicity
Gut bacteria metabolizes L-tryptophan into many products, including the antioxidant indole-3-propionic acid, the neurotransmitter tryptamine, and indole. Hydroxylation and sulfation of indole by hepatic enzymes generates the uremic toxin indoxyl sulfate.

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