PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (species: Eubacterium coprostanoligenes) increase Cholesterol's excretion.
Cholesterol (PubChem CID: 5997)
Eubacterium coprostanoligenes (Tax ID: 290054)
increase excretion
Gut microbial reduction of cholesterol generates coprostanol, which cannot be reabsorbed and is excreted. This transformation effectively removes cholesterol from circulation. Coprostanol represents up to 50% of the steroids in human feces, and germ-free mice colonized with microbes from high- and low-cholesterol–reducing patients produce distinct amounts of coprostanol. It is also possible that cholesterol-reducing bacteria decrease serum cholesterol. Specifically, in Eubacterium coprostanoligenes, coprostanol synthesis may involve oxidation to 5-cholesten-3-one followed by alkene isomerization to 4-cholesten-3-one, conjugate reduction, and ketone reduction. Inhibition of cholesterol reabsorption is a clinically validated strategy for lowering cholesterol.

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