PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (genus: Klebsiella) increase Melamine's toxicity.
Gut
Melamine (PubChem CID: 7955)
Klebsiella (Tax ID: 570)
23408055
increase toxicity
Gut microbiota deaminate melamine to generate ammonia and cyanuric acid. Cyanuric acid forms an insoluble complex with melamine in vivo, leading to renal toxicity. Klebsiella species are associated with cyanuric acid production.

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