PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Klebsiella) increase Melamine's toxicity.
Gut
Melamine (PubChem CID: 7955)
Klebsiella (Tax ID: 570)
23408055
increase toxicity
The gut microbiota deaminates melamine to generate ammonia and cyanuric acid. Cyanuric acid forms an insoluble complex with melamine in vivo, leading to renal toxicity. Klebsiella species are associated with cyanuric acid production.

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