PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (currently unknown members) increase Ellagic acid's activity.
Ellagic acid (PubChem CID: 5281855)
increase activity
Ellagic acid, a product of dietary polyphenols found in certain fruits, walnuts, and wines, is metabolized by the gut microbiota to release urolithins. Urolithin A is purported to have anti-proliferative effects in human colon cancer cells, mediating cell cycle arrest and co-treatment in vitro with urolithin A potentiates the anticancer effects of 5-FU and its pro-drug intermediate 5’-deoxy-5-fluorouridine.

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