| 85 | |
| Summary | Unknown microbes (species: Mycoplasma hyorhinis) decrease gemcitabine's activity. |
| Unknown | |
| gemcitabine (PubChem CID: 60750) | |
| Mycoplasma hyorhinis (Tax ID: 2100) | |
| 26322268 | |
| decrease activity | |
| Gemcitabine, a cytosine-based anticancer drug, is inactivated by the action of colonized bacteria in a tumor tissue, such as Mycoplasma. The Mycoplasma hyorhinis-encoded cytidine deaminase CDA_Hyor was found to be more catalytically active than its human equivalent and efficiently deaminates (inactivates) cytosine-based anticancer drugs. CDA_Hyor expression at the tumor site may result in selective drug inactivation and suboptimal therapeutic efficiency. |
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