PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Unknown microbes (species: Mycoplasma hyorhinis) decrease gemcitabine's activity.
gemcitabine (PubChem CID: 60750)
Mycoplasma hyorhinis (Tax ID: 2100)
decrease activity
Mycoplasmas may colonize tumor tissue in patients and inhibit the cytostatic activity of some drugs, e.g., gemcitabine. Mycoplasma hyorhinis-infected tumor cell cultures compared with non-infected tumor cell cultures. The M. hyorhinis-encoded CDAHyor was found to be more catalytically active than its human equivalent and efficiently deaminates (inactivates) cytosine-based anticancer drugs. CDAHyor expression at the tumor site may result in selective drug inactivation and suboptimal therapeutic efficiency.

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