PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Unknown microbes (species: Mycoplasma hyorhinis) decrease gemcitabine's activity.
Unknown
gemcitabine (PubChem CID: 60750)
Mycoplasma hyorhinis (Tax ID: 2100)
26322268
decrease activity
Gemcitabine a cytosine-based anticancer drugs, which inactivated by the action of colonized bacteria in tumaor tissue such as Mycoplasma. The M. hyorhinis-encoded CDAHyor was found to be more catalytically active than its human equivalent and efficiently deaminates (inactivates) cytosine-based anticancer drugs. CDAHyor expression at the tumor site may result in selective drug inactivation and suboptimal therapeutic efficiency.

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