PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

Detailed View

Summary Unknown microbes (species: Mycoplasma hyorhinis) decrease gemcitabine's activity.
gemcitabine (PubChem CID: 60750)
Mycoplasma hyorhinis (Tax ID: 2100)
decrease activity
Gemcitabine, a cytosine-based anticancer drug, is inactivated by the action of colonized bacteria in a tumor tissue, such as Mycoplasma. The Mycoplasma hyorhinis-encoded cytidine deaminase CDA_Hyor was found to be more catalytically active than its human equivalent and efficiently deaminates (inactivates) cytosine-based anticancer drugs. CDA_Hyor expression at the tumor site may result in selective drug inactivation and suboptimal therapeutic efficiency.

Browse Drug-Microbiome Relationship