| 87 | |
| Summary | Gut microbes (currently unknown members) affect ginsenoside's metabolic processing. |
| Gut | |
| ginsenoside (PubChem CID: 119307) | |
| unknown | |
| 16547074 | |
| affect metabolic processing | |
| Gut bacteria convert ginsenosides (the major bioactive components of ginseng) into metabolites that inhibit cytochrome P-450s and thus inhibit host xenobiotic metabolism. In summary: microbiota --> ginsenoside metabolism --> inhibition of Cyt P-450. ***** Note: intestinal metabolites have a wide range of inhibition of the P450-mediated metabolism; however, naturally occurring ginsenosides did not inhibit or weakly inhibited human CYP3A4, CYP2D6, CYP2C9, CYP2A6, or CYP1A2. |
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