PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (currently unknown members) increase Lovastatin's activity.
Gut
Lovastatin (PubChem CID: 53232)
unknown
24947972
increase activity
This study shows that gut microbes increase the convertion of lovastatin to active metabolite. The plasma concentration of the active hydroxyl acid metabolite of lovastatin is significantly lower in antibiotic-treated rats than controls.

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