PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Skin microbes (superkingdom: Bacteria) increase methyl red's degradation.
methyl red (PubChem CID: 10303)
Bacteria (Tax ID: 2)
increase degradation
Most skin bacteria possess azoreductase activity and are capable of reducing azo dyes (e.g., Methyl Red and Orange II) into N,N-dimethyl-p-phenylene diamine and 2-aminobenzoic acid. "Bacteria representing the genera Staphylococcus, Corynebacterium, Micrococcus, Dermacoccus and Kocuria, were able to reduce MR by 74-100 % in 24 h, with only three species unable to [completely] reduce the dye in that time." (Stingley et al. 2010) Note: Corynebacterium, Micrococcus, Dermacoccus and Kocuria are all members of phylum Actinobacteria, while Staphylococcus belongs to the phylum Firmicutes.

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