PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.3 (21 March 15)

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Summary Gut microbes (genus: Lactobacillus) decrease Levodopa's bioavailability.
Gut
Levodopa (PubChem CID: 6047)
Lactobacillus (Tax ID: 1578)
30659181
decrease bioavailability
This study shows how levodopa can be affected by gut microbiota having tyrosine decarboxylase gene (TDC). Tyrosine decarboxylase can convert levodopa to dopamine due to high structure similarity between tyrosine and levodopa. Dopamine can't be absorbed from jejunal as levodopa which required high dose frequency.

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