| 99 | |
| Summary | Gut microbes (genus: Lactobacillus) decrease Levodopa's bioavailability. |
| Gut | |
| Levodopa (PubChem CID: 6047) | |
| Lactobacillus (Tax ID: 1578) | |
| 30659181 | |
| decrease bioavailability | |
| This study shows how levodopa can be affected by the gut microbiota having the tyrosine decarboxylase (TDC) gene and expressing its activity. Tyrosine decarboxylase can convert levodopa to dopamine, because of the high structural similarity between tyrosine and levodopa, which leads to a decrease in bioavailability: unlike levodopa, dopamine cannot be absorbed from the jejunum. This interaction requires higher dose frequency to compensate for the lower absorption. |
Browse Drug-Microbiome Relationship
Home