PharmacoMicrobiomics: The Drug-Microbiome Portal

How Bugs Modulate Drugs?

Launched on 11/11/11; Current Release 1.5 (21 Mar 2021): Spring of Hope! (Release History)

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Summary Gut microbes (genus: Lactobacillus) decrease Levodopa's bioavailability.
Levodopa (PubChem CID: 6047)
Lactobacillus (Tax ID: 1578)
decrease bioavailability
This study shows how levodopa can be affected by the gut microbiota having the tyrosine decarboxylase (TDC) gene and expressing its activity. Tyrosine decarboxylase can convert levodopa to dopamine, because of the high structural similarity between tyrosine and levodopa, which leads to a decrease in bioavailability: unlike levodopa, dopamine cannot be absorbed from the jejunum. This interaction requires higher dose frequency to compensate for the lower absorption.

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